Wound measurement and complete wound healing adjudication are functional endpoints that CPC’s Endpoint Quality Intervention Program (EQuIP®) has a proven track record of successfully standardizing. Successful clinical trials targeting wound healing require centralized assessment of wound size and complete wound healing. Many clinical trials with wound closure or wound size as primary or secondary endpoints are challenged by significant variability in the methods of collection and assessment of wound data. Often, systematic errors in the acquisition, documentation, and measurement of the wound account for the inconsistent and highly variable wound assessments observed among recent clinical trials. Even if the site determines if the wound is completely healed, an external and objective wound core laboratory can provide critical confirmation.